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Abstract #2348

Resting-state fMRI predicts somatosensory-evoked BOLD fMRI in anesthetized mice

Hyun-Ji Shim1,2, Won Beom Jung1,3, Sangwoo Kim1, and Seong-Gi Kim1,2,3

1Center for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon, Republic of Korea, 2Department of Health Sciences and Technology (SAIHST), Sungkyunkwan University (SKKU), Seoul, Republic of Korea, 3Department of Biomedical Engineering (BME), Sungkyunkwan University (SKKU), Suwon, Republic of Korea

BOLD fMRI in rodents has been used to investigate brain functions in normal and diseased conditions. Until now, most animal fMRI have used anesthetics to reduce animal stress and minimize motions. Because anesthesia affects neurovascular coupling, maintaining the proper physiological condition under anesthesia is important. However, it is challenging in mice due to the limitation of physiological monitoring and high sensitivity to anesthetics used. Here we introduced ketamine and xylazine anesthesia in mice. Then, to examine the variability of fMRI response and indirectly measure the physiological condition, we use the resting state fMRI (RS-fMRI), which detects intrinsic brain state and connectivity.

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