Abstract #2349

Sleep Quality and Its Impact on Functional Connectivity and Cognitive Performance in HIV Infected Individuals

Yuchuan Zhuang¹, Lu Wang², Madalina Tivarus ³, Xing Qiu², Michael E. Yurcheshen⁴, Jianhui Zhong³, and Giovanni Schifitto⁵

¹Electrical and Computer Engineering, University of Rochester, Rochester, NY, United States, ²Dept of Biostatistics and Computational Biology, University of Rochester, Rochester, NY, United States, ³Department of Imaging Sciences, University of Rochester, Rochester, NY, United States, ⁴Department of Medicine, University of Rochester, Rochester, NY, United States, ⁵Department of Neurology, University of Rochester, Rochester, NY, United States

We investigated sleep quality in HIV infected individuals and its potential impact on cognitive performance and functional connectivity. Sleep quality was assessed using a self-report questionnaire, Pittsburgh Sleep Quality Index (PSQI). Cognitive performance was measured by a standard battery of neuropsychological tests assessing six cognitive domains, while functional connectivity was assessed by resting-state fMRI. We used a seed-based method to investigate the activation changes associated with the thalamus and frontoparietal network. We found a strong interaction between HIV infection and sleep quality, in the inferior temporal gyrus and the inferior parietal lobule but no deleterious effect on cognitive performance.

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