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Abstract #2359

Novel functional MRI study reveals cognitive deficits in diabetic peripheral neuropathy

Fangrong Zong1, Abdalla Z Mohamed1, Caroline KY Wong2, Michelle SJ Wong2, Kavita Venkataraman3, and Fatima A Nasrallah1

1Queensland Brain Institute, The University of Queensland, Brisbane, Australia, 2Agency for Science Technology and Research, Singapore, Singapore, Singapore, 3Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore

Paradigm design in the functional MRI acquisition is of paramount importance to investigate brain activities non-invasively. This is the first time to introduce imagination tasks of walking on floors with different surface stiffness in studying the consequence of a disease associated with diabetic peripheral neuropathy. Our results from the study-specific paradigms show a strong involvement of central nervous system in diabetic peripheral neuropathy subjects as well as cognitive deficits in sensation as caused by the disease.

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