Abstract #2362

Visual cortex and auditory cortex activation in early binocularly blind macaques: A BOLD-fMRI study using auditory stimuli

Lingjie Wu¹, Rong Wang², Zuohua Tang², Xinghuai Sun³, Xiaoyuan Feng⁴, Weijun Tang⁴, Wen Qian², Jie Wang¹, Yufeng Zhong⁵, Zebin Xiao², and Zhongshuai Zhang⁶

¹Otolaryngology, Eye & ENT Hospital of Fudan University, Shanghai, China, ²Radiology, Eye & ENT Hospital of Fudan University, Shanghai, China, ³Eye, Eye & ENT Hospital of Fudan University, Shanghai, China, ⁴Radiology, Huashan Hospital of Fudan University, Shanghai, China, ⁵Jinshan Hospital of Fudan University, Shanghai, China, ⁶Siemens Healthcare Ltd., Shanghai, China

We aimed to detect the changes in BOLD activity between the visual and auditory cortices of monocularly blind neonatal macaques by using pure tones as auditory stimuli. The changes in the BOLD response in the bilateral visual and auditory cortices were detected and further compared with the findings of the immunofluorescent staining. In monocularly bind macaques, we found a greater level of significant activation in the bilateral visual cortices while the number of activated volumes of the bilateral auditory cortices decreased. Therefore, cross-modal plasticity within the visual and auditory cortices was established in the monocularly blind macaques.

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