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Abstract #2364

Linear systems analysis of laminar sub-millimetre GE-EPI fMRI

Jelle A van Dijk1,2, Alessio Fracasso1,2,3, and Serge O Dumoulin1,2,4

1Spinoza Centre for Neuroimaging, Amsterdam, Netherlands, 2Experimental Psychology, Utrecht University, Utrecht, Netherlands, 3Radiology, University Medical Centre Utrecht, Utrecht, Netherlands, 4Applied and Experimental Psychology, VU University, Amsterdam, Netherlands

Nearly all fMRI analysis methods assume a linear relationship between local neuronal activity and the BOLD signal. This assumption is supported for fMRI at conventional resolutions (>1 mm isotropic). We assess whether linearity of the BOLD signal holds at sub-millimetre resolution, over cortical depth. We acquired functional GE 3D-EPI data at 0.7 mm isotropic resolution (TR/TE = 57/28 ms). Stimuli consisted of moving circular sine gratings at 80%, 20%, and 5% contrast. Our results suggest that response profiles for one contrast are linearly scaled response profiles of any other contrast.

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