How brain injuries affect the information content carried by signals of brain imaging modalities in patients with consciousness disorders has received little attention. We proposed a novel principal-components-analysis-based approach to quantify regional information content in patients in a minimally conscious state (MCS) and with unresponsive wakefulness syndrome (UWS). We show a reduction of regional information content in both patient populations. Importantly, our analyses revealed differential patterns in the reduction of information content in the sensory and memory compared with high-order cognitive systems in MCS and UWS; such observations are consistent with the clinical symptoms in the two DOC patient populations.
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