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Abstract #2374

Functional connectivity of intrinsic brain networks in chronic low back pain

Arman Tadjibaev1,2, William Cottam1,2,3, and Dorothee Auer1,2,3

1Arthritis UK Pain Centre, University of Nottingham, Nottingham, United Kingdom, 2Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 3NIHR Nottingham BRC, Nottingham, United Kingdom

Understanding pathological changes in intrinsic connectivity networks may advance our knowledge of chronic pain. We performed resting state seed-based functional connectivity analysis of main intrinsic brain networks in 34 chronic low back pain patients and 34 healthy controls. Results of present study are in accordance with studies that demonstrated weaker connectivity within the default mode network and reduced anticorrelation between the default mode and salience networks in chronic pain. In addition, we have identified abnormal sensorimotor network (SMN) connectivity and more profound medial prefrontal – hippocampal connectivity dysfunction in chronic low back pain.

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