Abstract #2375

Ventral intermediate nucleus involved in tremor and Postural instability and gait disability-related networks in Parkinson's disease

Qiaoling Zeng¹, Xiaojun Guan², Tao Guo², Jason C. F. Law Yan Lun², and Minming Zhang¹

¹Department of Radiology, The 2nd Affiliated Hospital, Department of Radiology, School of Medicine, Zhejiang University, hangzhou, China, ²The 2nd Affiliated Hospital, Department of Radiology, School of Medicine, Zhejiang University, hangzhou, China

To investigate the core pathophysiology between Parkinson's disease (PD) motor subtypes in subregions of thalamus and their different directory connectivity patterns, we collected multi-model magnetic resource imaging of 79 PD patients and 31 normal controls. We compared the grey matter volume and perfusion characteristics within the thalamus between PD phenotypes. Granger causality analysis was used to compare the effective connectivity between different subtypes. Our study revealed that core pathophysiology in tremor-dominant subtype may lie in the ventral intermediate nucleus, and a differential effective connectivity pattern existed in tremor and posture instability gait difficulty-related networks that related to behavioral heterogeneity in PD.

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