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Abstract #2380

Comparing cortical layer activation using gradient echo with phase regression and spin echo in the human visual cortex

Olivia W Stanley1,2, Alan B Kuurstra2, L Martyn Klassen1,2, Ravi S Menon1,2, and Joseph S Gati1,2

1Medical Biophysics, The University of Western Ontario, London, ON, Canada, 2Centre for Functional and Metabolic Mapping, The University of Western Ontario, London, ON, Canada

High resolution fMRI sequence selection is often a compromise between specificity to tissue (SE-EPI) and sensitivity to the BOLD effect (GE-EPI). Our work compared the laminar activation profiles of SE-EPI and GE-EPI once phase regression based macrovascular filtering has been applied. We demonstrated that GE-EPI with macrovascular filtering produces a laminar profile more similar to SE-EPI than GE-EPI without filtering. This shows that GE-EPI could be used for high resolution imaging and achieve a more sensitive profile when phase regression is included.

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