Abstract #2388

Reduced basal ganglia adaptability in patients with diabetic peripheral neuropathy

Yijia Zheng¹, Ye Wang^1,2, Geheng Yuan³, Xin Qi⁴, Rui Wang⁵, Zhanyang Ma³, Xiaohui Guo³, Xiaoying Wang^1,5, Jue Zhang^1,6, and Jing Fang^1,6

¹Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China, ²Neuroscience and Intelligent Media Institute, Communication University of China, Beijing, China, ³Department of Endocrinology, Peking University First Hospital, Beijing, China, ⁴Department of Plastic Surgery & Burns, Peking University First Hospital, Beijing, China, ⁵Department of Radiology, Peking University First Hospital, Beijing, China, ⁶College of Engineering, Peking University, Beijing, China

Diabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes mellitus and the patients often have no symptoms in the early stage. Notably, basal ganglia is an important hub in the sensorimotor loop, we hypothesized that dysfunction of basal ganglia in diabetic patients with DPN. Based on this hypothesis, we assessed the function of basal ganglia in diabetic patients using resting-state functional magnetic resonance imaging (fMRI). And our results found the reduced basal ganglia adaptability in DPN patients, which is expected to providing a new perspective for the guidance of early clinical diagnosis and efficacy evaluation.

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