Abstract #2387

Exploring the Origin of the Low Frequency Oscillation Signal in dual-echo Arterial Spin Labeling MRI

Xin Shen¹, Ho-Ching Yang¹, Blaise deB. Frederick^2,3, Danny JJ Wang⁴, and Yunjie Tong¹

¹Biomedical Engineering, Purdue University, West Lafayette, IN, United States, ²Brain Imaging Center, McLean Hospital, Belmont, MA, United States, ³Department of Psychiatry, Harvard University Medical School, Boston, MA, United States, ⁴Laboratory of FMRI Technology, University of Southern California, Los Angeles, CA, United States

Arterial spin labeling (ASL), which is a non-invasive technique providing perfusion values in the unit of ml/100g/min, has been limited by low signal-to-noise ratio (SNR). Although doing average of several repeating scans might be a solution, it is essential to identify the ‘physiological noise’, i.e. low frequency oscillations (LFOs). In a study of 9 healthy subjects, the similarity and amplitude of LFOs in ASL and in blood oxygenation level dependent (BOLD) were compared to explore the origin of LFOs as well as to discover a potential method for denoising and decreasing scanning time.

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