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Abstract #2387

Exploring the Origin of the Low Frequency Oscillation Signal in dual-echo Arterial Spin Labeling MRI

Xin Shen1, Ho-Ching Yang1, Blaise deB. Frederick2,3, Danny JJ Wang4, and Yunjie Tong1

1Biomedical Engineering, Purdue University, West Lafayette, IN, United States, 2Brain Imaging Center, McLean Hospital, Belmont, MA, United States, 3Department of Psychiatry, Harvard University Medical School, Boston, MA, United States, 4Laboratory of FMRI Technology, University of Southern California, Los Angeles, CA, United States

Arterial spin labeling (ASL), which is a non-invasive technique providing perfusion values in the unit of ml/100g/min, has been limited by low signal-to-noise ratio (SNR). Although doing average of several repeating scans might be a solution, it is essential to identify the ‘physiological noise’, i.e. low frequency oscillations (LFOs). In a study of 9 healthy subjects, the similarity and amplitude of LFOs in ASL and in blood oxygenation level dependent (BOLD) were compared to explore the origin of LFOs as well as to discover a potential method for denoising and decreasing scanning time.

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