Abstract #2390

Investigating Local and Global Connectivity to Inform Seizure Generation in Epilepsy: a Feasibility Study

Bianca De Blasi¹, Ilaria Boscolo Galazzo², Marian Galovic³, Enrico De Vita⁴, Ashley Groves⁵, Martin Tisdall⁶, Anna Barnes⁵, and Matthias Koepp³

¹Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ²University of Verona, Verona, Italy, ³UCL Institute of Neurology, London, United Kingdom, ⁴King's College London, London, United Kingdom, ⁵UCLH Institute of Nuclear Medicine, London, United Kingdom, ⁶Great Ormond Street Hospital, London, United Kingdom

In this work, we combined local and global functional connectivity to provide a more complete picture of the epileptogenic brain in temporal lobe epilepsy (TLE). Local functional connectivity was assessed by computing regional homogeneity (ReHo) maps which were compared between left (n=9) or right (n=10) TLE patients and controls (n=20). Areas of increased ReHo were used in a seed-to-voxel analysis to investigate global functional connectivity changes. We report a different pattern of alteration between left and right TLE patients. Left TLE patients showed a more profound bilateral increased connectivity which might highlight compensatory mechanisms.

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