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Abstract #2390

Investigating Local and Global Connectivity to Inform Seizure Generation in Epilepsy: a Feasibility Study

Bianca De Blasi1, Ilaria Boscolo Galazzo2, Marian Galovic3, Enrico De Vita4, Ashley Groves5, Martin Tisdall6, Anna Barnes5, and Matthias Koepp3

1Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 2University of Verona, Verona, Italy, 3UCL Institute of Neurology, London, United Kingdom, 4King's College London, London, United Kingdom, 5UCLH Institute of Nuclear Medicine, London, United Kingdom, 6Great Ormond Street Hospital, London, United Kingdom

In this work, we combined local and global functional connectivity to provide a more complete picture of the epileptogenic brain in temporal lobe epilepsy (TLE). Local functional connectivity was assessed by computing regional homogeneity (ReHo) maps which were compared between left (n=9) or right (n=10) TLE patients and controls (n=20). Areas of increased ReHo were used in a seed-to-voxel analysis to investigate global functional connectivity changes. We report a different pattern of alteration between left and right TLE patients. Left TLE patients showed a more profound bilateral increased connectivity which might highlight compensatory mechanisms.

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