Meeting Banner
Abstract #2391

Oxycodone BOLD activation and connectivity signature by Mu opioid receptor in anaesthetized mice fMRI

Md Taufiq Nasseef1, Emmanuel Darcq1, Jai Puneet Singh1, Praveen Kulkarni2, and Brigitte L. Kieffer1

1Douglas Mental Health University Institute, Department of Psychiatry, Mcgill University, Montreal, QC, Canada, 2Center for Translational Neuro-Imaging, Northeastern University, Boston, MA, United States

Mu opioid receptors (MORs) mediate biological effects of oxycodone, including their analgesic and euphoric properties. To assess the effect of oxycodone on neuronal communication, we used non-invasive mouse fMRI and tested oxycodone effects in both wild-type and MOR-knockout mice in order to extract MOR-dependent effects. Analysis was performed 2 to 7 minutes after drug administration, a time where BOLD activation was minimal in knockout animals. Here, we show that oxycodone reduces functional activity of the Nucleus Accumbens seed with several brain regions, establishing a first receptor-mediated FC connectivity signature of a MOR agonist.

This abstract and the presentation materials are available to members only; a login is required.

Join Here