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Abstract #2401

Functional connectivity sensitivity to image acceleration and orientation in simultaneous PET/MRI

Alessandro Palombit1,2, Marco Castellaro1,2, Erica Silvestri1,2, Enrico De Vita3, Diego Cecchin2,4, and Alessandra Bertoldo1,2

1Department of Information Engineering, University of Padova, Padova, Italy, 2Padova Neuroscience Center, University of Padova, Padova, Italy, 3Department of Biomedical Engineering, King's College London, London, United Kingdom, 4Department of Diagnostic Medical Sciences, University of Padova, Padova, Italy

Resting state fMRI (rs-fMRI) permits in-vivo characterization of brain’s functional connectivity (FC). Multi-Band accelerated EPI allows to improve the temporal resolution of rs-fMRI data and, potentially, to achieve a better characterization of the brain network correlations. However, the impact of image acceleration and orientation on FC structure has not been quantified. In this work we investigated FC changes related to image acceleration effects in a test/retest rs-fMRI protocol. We found FC differences involving relevant networks, confirmed even by graph analysis of the FC maps. Our findings explore the lower bound of single-subject FC reliability and network-dependent acceleration sensitivity.

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