PET/MRI scanner is the ideal instrument to simultaneously study brain’s metabolism and fMRI-based functional connectivity (FC). State-of-the-art fMRI multiband (MB) EPI sequences on those scanners can be limited by the PET-transparent head coil receiver capabilities as the longitudinal coil elements organisation along head-feet direction is theoretically unable to provide sensitivity variation along this axis. In this work we provided optimal sequence settings for FC studies encompassing available out-of-plane (MB) and in-plane (iPAT) accelerations with two slice orientations demonstrating MB-EPI reliability for FC studies and how non conventional slice orientations can enhance supported MB acceleration factors.
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