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Abstract #2402

Multiband-enabled Resting State Functional Connectivity Mapping in Simultaneous PET/MRI

Alessandro Palombit1,2, Erica Silvestri1,2, Marco Castellaro1,2, Enrico De Vita3, Diego Cecchin2,4, and Alessandra Bertoldo1,2

1Department of Information Engineering, University of Padova, Padova, Italy, 2Padova Neuroscience Center, University of Padova, Padova, Italy, 3Department of Biomedical Engineering, King's College London, London, United Kingdom, 4Department of Diagnostic Medical Sciences, University of Padova, Padova, Italy

PET/MRI scanner is the ideal instrument to simultaneously study brain’s metabolism and fMRI-based functional connectivity (FC). State-of-the-art fMRI multiband (MB) EPI sequences on those scanners can be limited by the PET-transparent head coil receiver capabilities as the longitudinal coil elements organisation along head-feet direction is theoretically unable to provide sensitivity variation along this axis. In this work we provided optimal sequence settings for FC studies encompassing available out-of-plane (MB) and in-plane (iPAT) accelerations with two slice orientations demonstrating MB-EPI reliability for FC studies and how non conventional slice orientations can enhance supported MB acceleration factors.

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