Abstract #2418

A MRI-based breast density measure which is directly comparable to mammographic density

Jie Ding¹, Alison T Stopeck^2,3, Yi Gao^4,5,6, Marilyn T Marron⁷, Betsy C Wertheim⁷, Maria I Altbach^7,8, Jean-Philippe Galons^7,8, Denise J Roe^7,9, Fang Wang², Gertraud Maskarinec¹⁰, Cynthia A Thomson⁷, Patricia A Thompson^2,11, and Chuan Huang^1,12,13,14

¹Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, ²Stony Brook University Cancer Center, Stony Brook, NY, United States, ³Hematology and Oncology, Stony Brook Medicine, Stony Brook, NY, United States, ⁴Biomedical Engineering, Shenzhen University, Shenzhen, China, ⁵Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Shenzhen, China, ⁶Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, United States, ⁷University of Arizona Cancer Center, Tucson, AZ, United States, ⁸Medical Imaging, University of Arizona, Tucson, AZ, United States, ⁹Epidemiology and Biostatistics, University of Arizona, Tucson, AZ, United States, ¹⁰University of Hawaii Cancer Center, Honolulu, HI, United States, ¹¹Pathology, Stony Brook Medicine, Stony Brook, NY, United States, ¹²Computer Science, Stony Brook University, Stony Brook, NY, United States, ¹³Radiology, Stony Brook Medicine, Stony Brook, NY, United States, ¹⁴Psychiatry, Stony Brook Medicine, Stony Brook, NY, United States

High breast density is an independent risk factor for breast cancer. Mammography, the most widely used method for breast density determination, is limited by ionizing radiation exposure and its relatively low reliability for density assessment. We propose an automated, safe, and highly reproducible breast density measurement based on fat-water decomposition MRI. The technique yields a measure directly comparable to mammographic density which is easy for clinicians to use and for patients to understand.

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