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Abstract #2418

A MRI-based breast density measure which is directly comparable to mammographic density

Jie Ding1, Alison T Stopeck2,3, Yi Gao4,5,6, Marilyn T Marron7, Betsy C Wertheim7, Maria I Altbach7,8, Jean-Philippe Galons7,8, Denise J Roe7,9, Fang Wang2, Gertraud Maskarinec10, Cynthia A Thomson7, Patricia A Thompson2,11, and Chuan Huang1,12,13,14

1Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, 2Stony Brook University Cancer Center, Stony Brook, NY, United States, 3Hematology and Oncology, Stony Brook Medicine, Stony Brook, NY, United States, 4Biomedical Engineering, Shenzhen University, Shenzhen, China, 5Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Shenzhen, China, 6Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, United States, 7University of Arizona Cancer Center, Tucson, AZ, United States, 8Medical Imaging, University of Arizona, Tucson, AZ, United States, 9Epidemiology and Biostatistics, University of Arizona, Tucson, AZ, United States, 10University of Hawaii Cancer Center, Honolulu, HI, United States, 11Pathology, Stony Brook Medicine, Stony Brook, NY, United States, 12Computer Science, Stony Brook University, Stony Brook, NY, United States, 13Radiology, Stony Brook Medicine, Stony Brook, NY, United States, 14Psychiatry, Stony Brook Medicine, Stony Brook, NY, United States

High breast density is an independent risk factor for breast cancer. Mammography, the most widely used method for breast density determination, is limited by ionizing radiation exposure and its relatively low reliability for density assessment. We propose an automated, safe, and highly reproducible breast density measurement based on fat-water decomposition MRI. The technique yields a measure directly comparable to mammographic density which is easy for clinicians to use and for patients to understand.

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