Phyllodes tumors are uncommon, biphasic, fibroepithelial lesions of the breast, characterized by leafy stromal fronds capped by benign bilayered epithelium. Grading of breast phyllodes tumors is critical for diagnosis, treatment options and preoperative evaluation. This study is to assess the feasibility of diffusion weighted image (DWI) for determining phyllodes tumors grades in the femoral breast. Our results reveal that histogram analysis of apparent diffusion coefficient (ADC) parameters derived from DWI can be used to classify the benign and malignant breast phyllodes tumors patients. This can be applied for clinical diagnose and treatment.