Abstract #2439

Using a hybrid multibreath hyperpolarized (HP) 129Xe imaging technique for simultaneous assessment of lung function and structure in a two-hit radiation induced lung injury (RILI) model.

Sarmad Siddiqui¹, Hooman Hamedani¹, Yi Xin¹, Luis Loza¹, Faraz Amzajerdian¹, Mehrdad Pourfathi¹, Stephen Kadlecek¹, Kai Ruppert¹, Harrilla Profka¹, Rahim R. Rizi¹, Shampa Chatterjee², and Ian Duncan¹

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Physiology, University of Pennsylvania, Philadelphia, PA, United States

In this study we developed a two-hit hemi-thorax radiation-induced lung injury (RILI) model that better simulates the etiology of the disease in humans, and characterized it via a multibreath hyperpolarized (HP) 129Xe imaging technique to assess lung function and structure one month post-radiation. We observed an increased PAO2 of 145±41 Torr in the radiated lung compared to 124±40 Torr in the contralateral lung. We also observed a corresponding decrease in oxygen uptake in the radiated lung. The preliminary findings suggest that HP 129Xe-derived functional parameters, particularly changes in the alveolar oxygen tension and oxygen uptake can serve as biomarkers during the early fibrotic stage of RILI.

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