Meeting Banner
Abstract #2439

Using a hybrid multibreath hyperpolarized (HP) 129Xe imaging technique for simultaneous assessment of lung function and structure in a two-hit radiation induced lung injury (RILI) model.

Sarmad Siddiqui1, Hooman Hamedani1, Yi Xin1, Luis Loza1, Faraz Amzajerdian1, Mehrdad Pourfathi1, Stephen Kadlecek1, Kai Ruppert1, Harrilla Profka1, Rahim R. Rizi1, Shampa Chatterjee2, and Ian Duncan1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Physiology, University of Pennsylvania, Philadelphia, PA, United States

In this study we developed a two-hit hemi-thorax radiation-induced lung injury (RILI) model that better simulates the etiology of the disease in humans, and characterized it via a multibreath hyperpolarized (HP) 129Xe imaging technique to assess lung function and structure one month post-radiation. We observed an increased PAO2 of 145±41 Torr in the radiated lung compared to 124±40 Torr in the contralateral lung. We also observed a corresponding decrease in oxygen uptake in the radiated lung. The preliminary findings suggest that HP 129Xe-derived functional parameters, particularly changes in the alveolar oxygen tension and oxygen uptake can serve as biomarkers during the early fibrotic stage of RILI.

This abstract and the presentation materials are available to members only; a login is required.

Join Here