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Abstract #2438

129Xe signal dynamics and chemical shift in the cardio-pulmonary circuit using cardiac-gated hyperpolarized 129Xe NMR

Graham Norquay1 and Jim M Wild1

1University of Sheffield, Sheffield, United Kingdom

The sensitivity of the 129Xe chemical shift to red blood cell oxygenation makes hyperpolarized 129Xe MR spectroscopy a promising technique for measurement of blood oxygenation in vivo. In addition, dissolved phase 129Xe MRS is of interest as a biomarker of gas exchange and interstitial lung disease. Both the signal dynamics and chemical shift of 129Xe have been shown to be modulated by the cardiac cycle, potentially adding confounding effects to interpretation of the 129Xe MRS chemical shift. In this study, we demonstrate that cardiac-gating in 129Xe MRS reduces the variability in the measured dissolved 129Xe signal and chemical shift in the cardio-pulmonary circuit.

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