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Abstract #2437

Revealing Pulmonary Gas Transport Dynamics using a 3D Radial Hyperpolarized Xenon MRI Acquisition with Variable Flip Angles

Faraz Amzajerdian1, Kai Ruppert1, Hooman Hamedani1, Yi Xin1, Ian F. Duncan1, Harrilla Profka1, Mehrdad Pourfathi1, Sarmad Siddiqui1, Luis Loza1, Stephen Kadlecek1, and Rahim R. Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States

We demonstrated that reducing the flip angle drives the distribution of acquired dissolved-phase xenon downstream towards the heart. By exploiting this principle, the dynamics of pulmonary gas transport were captured through a single 3D double golden means radial acquisition with linearly decreasing flip angles. Reconstruction with a sliding window generated a series of consecutive images with declining average flip angles, depicting the gradual uptake and accumulation of xenon by the heart and lungs.

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