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Abstract #2436

Hyperpolarized 129Xe MR functional imaging to monitor the response of the human lungs after segmental lipopolysaccharide challenge

Agilo Luitger Kern1,2, Heike Biller2,3, Filip Klimes1,2, Andreas Voskrebenzev1,2, Marcel Gutberlet1,2, Alexander Rotärmel1,2, Christian Schönfeld1,2, Julius Renne1,2, Olaf Holz2,3, Kun Qing4, Kai Ruppert5, Frank Wacker1,2, Jens Hohlfeld2,3, and Jens Vogel-Claussen1,2

1Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, 2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany, 3Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany, 4Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States, 5Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Hyperpolarized 129Xe MRI has been shown to be sensitive to inflammatory changes after lung provocation by lipopolysaccharide (LPS) in an animal model. The purpose of this work was to investigate feasibility of monitoring the response of the human lungs after segmental LPS challenge using 129Xe MRI. Dissolved-phase imaging and chemical shift saturation recovery were employed to assess inflammatory changes and to compare MRI results with inflammatory cell counts from bronchoalveolar lavage. Both MRI methods show a significant reduction of the 129Xe in red blood cells and lung tissue ratio in the affected region but no significant correlations with inflammatory cell counts.

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