Abstract #2436

Hyperpolarized 129Xe MR functional imaging to monitor the response of the human lungs after segmental lipopolysaccharide challenge

Agilo Luitger Kern^1,2, Heike Biller^2,3, Filip Klimes^1,2, Andreas Voskrebenzev^1,2, Marcel Gutberlet^1,2, Alexander Rotärmel^1,2, Christian Schönfeld^1,2, Julius Renne^1,2, Olaf Holz^2,3, Kun Qing⁴, Kai Ruppert⁵, Frank Wacker^1,2, Jens Hohlfeld^2,3, and Jens Vogel-Claussen^1,2

¹Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ²Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany, ³Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany, ⁴Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States, ⁵Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Hyperpolarized ¹²⁹Xe MRI has been shown to be sensitive to inflammatory changes after lung provocation by lipopolysaccharide (LPS) in an animal model. The purpose of this work was to investigate feasibility of monitoring the response of the human lungs after segmental LPS challenge using ¹²⁹Xe MRI. Dissolved-phase imaging and chemical shift saturation recovery were employed to assess inflammatory changes and to compare MRI results with inflammatory cell counts from bronchoalveolar lavage. Both MRI methods show a significant reduction of the ¹²⁹Xe in red blood cells and lung tissue ratio in the affected region but no significant correlations with inflammatory cell counts.

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