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Abstract #2435

Measuring the Impact of PEEP on Pulmonary Gas Transport Using Hyperpolarized Xenon-129 Dissolved-Phase MRI

Kai Ruppert1, Hooman Hamedani1, Faraz Amzajerdian1, Luis Loza1, Yi Xin1, Ian F. Duncan1, Harilla Profka1, Sarmad Siddiqui1, Mehrdad Pourfathi1, Maurizio F. Cereda1, Stephen Kadlecek1, and Rahim R. Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States

Higher positive end-expiratory pressure (PEEP) during mechanical ventilation can result in improved oxygenation, but it can also give rise to ventilator-induced lung injury. In this work, we used a rabbit model to evaluate the sensitivity of a hyperpolarized xenon-129 MRI technique that allows a comprehensive assessment of the pulmonary gas-transport by the entire lung for monitoring the impact of PEEP on lung function. We observed that increased PEEP resulted in a large decrease in pulmonary gas transport that is most likely linked to a lengthened pulmonary transit time.

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