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Abstract #2441

Next-Generation Automated Clinical-Scale Batch-Mode Xe-129 Hyperpolarizer

Panayiotis Nikolaou1, Aaron M Coffey2, Bryce Kidd3, Megan Murphy3, Boyd M Goodson3, Michael J Barlow4, and Eduard Y Chekmenev5

1VUIIS, Vanderbilt University Medical Center, Nashville, TN, United States, 2Vanderbilt University Medical Center, Nashville, TN, United States, 3Southern Illinois University Carbondale, Carbondale, IL, United States, 4University of Nottingham, Nottingham, United Kingdom, 5Radiology, Vanderbilt University Medical Center, Nashville, TN, United States

Over the last two decades there have been many advances in the field of hyperpolarized (HP) noble gas production and imaging, largely enabled by the development of low-cost, high-power frequency-narrowed laser diode arrays (LDAs) and the improvement of 129Xe polarizer technology in general. Here we present the development and features of the new 3rd-generation Batch-Mode 129Xe hyperpolarizer. As with most previous 129Xe polarizers, the new device utilizes Spin Exchange Optical Pumping (SEOP), a process in which resonant, circularly polarized photons optically pump Rb electrons, which in turn hyperpolarize the 129Xe nuclear spins via hyperfine interactions (the “spin-exchange” process).

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