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Abstract #2442

A paired approach to the segmentation of proton and hyperpolarized gas MR images of the lungs

Alberto M Biancardi1,2, Laure Acunzo1, Helen Marshall1, Bilal A Tahir1,3, Paul JC Hughes1, Laurie Smith1,4, Nicholas D Weatherley1, Guilhelm J Collier1, and Jim M Wild1,2

1Polaris, The University of Sheffield, Sheffield, United Kingdom, 2INSIGNEO, The University of Sheffield, Sheffield, United Kingdom, 3Academic Unit of Clinical Oncology, The University of Sheffield, Sheffield, United Kingdom, 4Sheffield Children’s Hospital, Sheffield Children’s NHS Foundation Trust and Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom

Quantitative analyses of hyperpolarized gas and 1H lung MRI together provide quantitative information on lung obstruction. Quantification requires segmentation of the ventilated and non-ventilated regions of the hyperpolarized gas MRI and definition of the lung cavity from the paired 1H MRI. Spatial fuzzy c-means segmentation was developed to segment these image pairs simultaneously. Error measures with respect to manual reference segmentations and qualitative grading showed significant improvements when compared to an established method. This work may help towards standardisation and automation of lung ventilation image analysis, and help improve accuracy and reproducibility.

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