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Abstract #2443

A Study of Lung Function Variability in Chronic Obstructive Pulmonary Disease Using Hybrid Hyperpolarized 3He Imaging

Hooman Hamedani1, Ryan Baron1, Sarmad Siddiqui1, Yi Xin1, Mary Spencer1, Faraz Amzajerdian1, Stephen Kadlecek1, Kai Ruppert1, Mehrdad Pourfathi1, Luis Loza1, Ian Duncan1, Tahmina Achekzai1, Maurizio Cereda2, and Rahim R. Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States

To better understand variable lung function in COPD, we imaged a subset of COPDGene subjects at baseline, one week post-baseline and one month post-baseline using a multifaceted hyperpolarized (HP) 3He scheme to measure apparent diffusion coefficient (ADC), fractional ventilation (FV), alveolar oxygen tension (PAO2) and oxygen uptake (R) variability.

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