Abstract #2456

Effects of Neonatal Lung Abnormalities on Parenchymal R2* Estimates

Andrew David Hahn¹, Nara Higano^2,3, Jean Tkach⁴, Laura Walkup², Robert Thomen⁵, Xuefeng Cao^2,6, Stephanie Merhar⁷, Paul Kingma⁷, Jason Woods^2,3, and Sean Fain¹

¹Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ²Center for Pulmonary Imaging Research, Division of Pulmonary Medicine and Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ³Physics, Washington University in St. Louis, St. Louis, MO, United States, ⁴Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ⁵Radiology, University of Missouri, Columbia, MO, United States, ⁶Physics, University of Cincinnati, Cincinnati, OH, United States, ⁷Perinatal Institute, Division of Neonatology and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States

We estimate pulmonary tissue densities (TD) and R₂* in neonatal intensive care unit patients with and without diagnoses of lung disease as well as in healthy adults using multi-echo 3D ultrashort echo time MRI. As anticipated, a clear negative relationship between TD and R₂* is evident. However, after correcting for TD variation, we find significant differences in R₂* between diseased and non-diseased neonates, suggesting that MRI can probe differences in susceptibility and/or sub-voxel tissue geometry which may increase understanding of neonatal lung tissue pathologies.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.