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Abstract #2471

Probing changes in lung physiology in COPD using CT, perfusion MRI and hyperpolarized xenon-129 MRI

Kun Qing1, Nicholas J. Tustison1, John P. Mugler, III1, Jaime F. Mata1, Zixuan Lin1, Li Zhao2, Da Wang3, Xue Feng1, Kai Ruppert4, Talissa A. Altes5, Joanne M. Cassani5, and Y. Michael Shim1

1University of Virginia, Charlottesville, VA, United States, 2Beth Israel Deaconess Medical Center, Boston, MA, United States, 3University of Washington, Seattle, WA, United States, 4University of Pennsylvania, Philadelphia, VA, United States, 5University of Missouri School of Medicine, Columbia, MO, United States

In this study, by using chest CT, Gadolinium-enhanced perfusion MRI, and hyperpolarized xenon-129 ventilation and gas uptake MRI, we assessed the quantitative changes in tissue density, pulmonary perfusion and gas uptake in patients with COPD compared to normal subjects. We found evidence for compensatory pulmonary vasoconstriction to match impairment of ventilation, and also pulmonary shunt and dead space. By incorporating a new lobar segmentation method for proton MRI, we performed statistical analysis to evaluate the regional interrelationships among different measures. We demonstrated that xenon-129 MRI has high potential to identify changes of multiple aspects of lung physiology in one acquisition.

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