Abstract #2472

Combination of Perfluoropropane and oxygen-enhanced MRI-derived washout kinetics for detection of ischemic injury to lungs in a porcine ex-vivo perfusion system

Julius Renne^1,2, Marcel Gutberlet^1,2, Andreas Voskrebenzev^1,2, Agilo Kern^1,2, Till Kaireit^1,2, Jan Bernd Hinrichs^1,2, Peter Braubach³, Christiane S Falk^2,4, Klaus Höffler⁵, Gregor Warnecke^2,5, Axel Haverich⁵, Frank Wacker¹, Jens Vogel-Claussen^1,2, and Norman Zinne^2,5

¹Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ²Integrated Research and Treatment Center Transplantation (IfB-Tx), Hannover, Germany, ³Institute for Pathology, Hannover Medical School, Hannover, Germany, ⁴Institute for Transplant Immunology, Hannover Medical School, Hannover, Germany, ⁵Clinic for Cardiothoracic and Transplantation Surgery, Hannover Medical School, Hannover, Germany

Ex-vivo lung perfusion and ventilation systems are a promising new tool for conditioning marginal lung allografts. However, reliable biomarkers for evaluating graft function are missing. In this study MRI-derived fluorine and oxygen washout times are to be evaluated as lung function parameters in a porcine model of ischemia. Washout time for oxygen is prolonged while fluorine washout is not in lungs after warm ischemia compared to normal controls, which might reflect pulmonary edema limiting oxygen diffusion. Determination of fluorine and oxygen washout is feasible in an ex-vivo lung perfusion system and seems to be promising tools for evaluating graft function.

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