Abstract #2473

Mapping of Ventilation/Perfusion Ratios in the human lung using 19F MRI of Perfluoropropane

Arnd Obert^1,2, Marcel Gutberlet^1,2, Alexander Rotärmel^1,2, Frank Wacker^1,2, and Jens Vogel-Claussen^1,2

¹Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ²Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany

In this work, the correlation between longitudinal relaxation time (T₁), alveolar partial pressure and ventilation-perfusion ratio (V/Q) of an inhaled fluorinated gas is used to compute quantitative V/Q maps of the human lung. The trapping of inert Perfluoropropane (C₃F₈) in poorly ventilated regions of the lung (low V/Q) leads to an increase of its alveolar partial pressure which is detectable as an increase of T₁ in ¹⁹F MR Imaging. Here, V/Q maps of three patients with Chronic Obstructed Pulmonary Disease (COPD) were calculated and compared to a V/Q map of a healthy volunteer.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.