Meeting Banner
Abstract #2473

Mapping of Ventilation/Perfusion Ratios in the human lung using 19F MRI of Perfluoropropane

Arnd Obert1,2, Marcel Gutberlet1,2, Alexander Rotärmel1,2, Frank Wacker1,2, and Jens Vogel-Claussen1,2

1Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, 2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany

In this work, the correlation between longitudinal relaxation time (T1), alveolar partial pressure and ventilation-perfusion ratio (V/Q) of an inhaled fluorinated gas is used to compute quantitative V/Q maps of the human lung. The trapping of inert Perfluoropropane (C3F8) in poorly ventilated regions of the lung (low V/Q) leads to an increase of its alveolar partial pressure which is detectable as an increase of T1 in 19F MR Imaging. Here, V/Q maps of three patients with Chronic Obstructed Pulmonary Disease (COPD) were calculated and compared to a V/Q map of a healthy volunteer.

This abstract and the presentation materials are available to members only; a login is required.

Join Here