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Abstract #2480

Quantifying Regional Lung Function in Interstitial Lung Disease with Hyperpolarized Xenon-129 3D SB-CSI

Mackenzie Carlson1, Borna Mehrad2, Yun Shim1, Nicholas Tustison1, John Mugler1, Talissa Altes1,3, Lucia Flors3, Grady Miller1, and Jaime Mata1

1University of Virginia, Charlottesville, VA, United States, 2University of Florida, Gainesville, FL, United States, 3University of Missouri, Columbia, MO, United States

In this study, lung ventilation and gas uptake/exchange was assessed in healthy and interstitial lung disease (ILD) subject populations using 3D Single-Breath Chemical Shift Imaging, a combination of MR spectroscopic imaging and hyperpolarized xenon-129 gas imaging. By probing metrics such as Tissue/RBC, Tissue/Gas, RBC/Gas, T2* and chemical shifts in lung parenchyma and red blood cells, we find statistically significant distinctions in the lung physiology between healthy and ILD subjects.

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