Abstract #2479

Absolute Reference for Dissolved-Phase 129Xe Spectroscopy Leads to Peak Reassignment

Michael A Antonacci^1,2, Le Zhang^2,3, Alex Burant^1,2, Drew McCallister^1,2, and Rosa Tamara Branca^1,2

¹Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ²Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ³Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Dissolved-phase ¹²⁹Xe (DPXe) chemical shift (CS) measurements could benefit from a robust reference system that can provide consistent CS values independently of gas partial pressures, lung inflation, subject position, and shimming conditions. We demonstrate that, by referencing the DPXe frequency to that of nearby protons, consistent CS values can be obtained, both in vitro and in vivo, enabling correct assignment of some of the spectral lines observed in vivo.

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