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Abstract #2478

Hyperpolarized 129Xe gas and ultra-short echo MRI for evaluation of structure-function correlates in cystic fibrosis lung disease: a comparison of analysis methods

Robert Thomen1, Laura Walkup2, David Roach2, Nara Higano2, Zackary Cleveland2, Andrew Schapiro3, Alan Brody3, John P Clancy4, and Jason Woods2

1Radiology and BioEngineering, University of Missouri, Columbia, MO, United States, 2Center for Pulmonary Imaging Research, Cincinnati Children's Hospital, Cincinnati, OH, United States, 3Radiology, Cincinnati Children's Hospital, Cincinnati, OH, United States, 4Pulmonary Medicine, Cincinnati Children's Hospital, Cincinnati, OH, United States

A number of techniques for analysis of hyperpolarized gas (HPG) images have emerged and demonstrated sensitivity to lung disease severity. However, the precise extent of lung function decline due to specific pathologies associated with obstructive lung disease has not been established. Here we have performed HPG 129Xe analysis using 3 common methods from the literature (mean-anchored, percentile-anchored, and k-means methods) in order to evaluate correlations with structural pathologies identified in ultra-short echo-time (UTE) images. The presence of bronchiectasis and mucus plugging correlated best with whole-lung ventilation defect percentage (VDP). Consolidation and air-trapping demonstrated weaker (though still significant) correlation with VDP.

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