Abstract #2477

SNR and Dose Requirements for Quantitative 6-Zone Analysis of Hyperpolarized (129)Xe Ventilation MRI

Fei Tan¹, Mu He², Leith Rankine³, Rohan S. Virgincar¹, John C. Nouls⁴, Steven Shipes⁴, and Bastiaan Driehuys^1,3,4

¹Department of Biomedical Engineering, Duke University, Durham, NC, United States, ²Department of Electrical and Computer Engineering, Duke University, Durham, NC, United States, ³Department of Medical Physics, Duke University, Durham, NC, United States, ⁴Department of Radiology, Duke University, Durham, NC, United States

Hyperpolarized (HP) ¹²⁹Xe ventilation MRI can be used for non-invasive assessment of lung obstruction. However, the minimum ¹²⁹Xe dose to obtain HP ¹²⁹Xe ventilation MRI with sufficient signal-to-noise ratio (SNR) for reliable quantitative analysis has not yet been established. In this work, we introduced the reader-based six-zone analysis, which is used with ¹³³Xe and ^99mTc ventilation and perfusion scintigraphy, and applied to Rician noise degraded ¹²⁹Xe ventilation MRI of COPD patients. We found that the minimum required SNR for 6-zone quantification of ventilation is 4.4±5.8 (mean±SD), which suggests a minimum required ¹²⁹Xe dose equivalent of 89.2 ml for this resolution.

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