Development of sensitive imaging biomarkers to differentiate health from disease is an important research topic in pulmonary MRI. This work aimed to make use of the rich spatial and signal intensity information in hyperpolarized gas MR ventilation images to determine metrics of ventilation heterogeneity. Retrospective analysis was performed on 3He ventilation images acquired from healthy volunteers and patients with cystic fibrosis, asthma and chronic obstructive pulmonary disease.
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