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Abstract #2476

Assessment of ventilation heterogeneity using hyperpolarized gas MRI histogram analysis

Paul J.C. Hughes1, Laurie Smith1,2, Felix Horn1, Alberto M. Biancardi1, Neil Stewart1, Graham Norquay1, Madhwesha Rao1, Ina Aldag2, Chris Taylor2, Helen Marshall1, Guilhem Collier1, and Jim M. Wild1

1POLARIS, Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom, 2Sheffield Children’s Hospital,Sheffield Children’s NHS Foundation Trust; and Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom

Development of sensitive imaging biomarkers to differentiate health from disease is an important research topic in pulmonary MRI. This work aimed to make use of the rich spatial and signal intensity information in hyperpolarized gas MR ventilation images to determine metrics of ventilation heterogeneity. Retrospective analysis was performed on 3He ventilation images acquired from healthy volunteers and patients with cystic fibrosis, asthma and chronic obstructive pulmonary disease.

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