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Abstract #2496

A Dedicated Protocol for Fat Fraction Mapping in Obese Patients: Preliminary Findings in Skeletal Muscle

Naomi S Sakai1, Timothy Bray1, Alan Bainbridge2, Rachel Batterham3, Stuart Taylor1, and Margaret Hall-Craggs1

1Centre for Medical Imaging, University College London, London, United Kingdom, 2Department of Medical Physics, University College London Hospital, London, United Kingdom, 3Centre for Obesity Research, University College London, London, United Kingdom

Obesity is associated with ectopic fat deposition and chronic inflammation in skeletal muscle (SM), which contributes to insulin resistance. Novel treatments for obesity such as bariatric surgery can reduce insulin resistance by reducing ectopic fat deposition, but this effect is inconsistent and poorly understood. Therefore, we need a fast, non-invasive method that can help to study the link between ectopic fat deposition and insulin resistance. Here, we describe a protocol for scanning obese patients, which is fast, tolerable and accurate, and reveals significant changes in SM proton density fat fraction (PDFF) in obese patients.

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