Abstract #2499

Magnetic Resonance Imaging and Spectroscopic Investigation of interscapular BAT and Skeletal Muscle IMCL in High Intensity Exercise Trained Rats

Venkatesh Gopalan¹, Rengaraj Anantharaj¹, Le Thi Thu Giang¹, Sanjay Kumar Verma¹, Jadegoud Yaligar¹, Anna Ulyanova¹, Karthik Mallilankaraman², and S Sendhil Velan¹

¹Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore, ²Mitochondrial Physiology and Metabolism Lab, Department of Physiology, National University of Singapore, Singapore, Singapore

There is a large interest in developing non-pharmacological approaches such as exercise and nutritional compounds for activating BAT to improve metabolic health. In this study, we have investigated the effect of high intensity exercise on interscapular BAT and Intramyocellular lipids (IMCL) from skeletal muscle of rats. Exercise-induced adrenergic receptor stimulation improves quality of iBAT by remodeling of WAT into beige fat and improved mitochondrial fatty acid oxidation. Skeletal muscle IMCL also reduced with exercise along with increased PGC-1α expression due to energy expenditure.

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