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Abstract #2502

Metabolic Imaging of Brown Adipose Tissue in Response to High Glycaemic Diet and Systemic Metabolic Effects on Whole Body Fat Metabolism

Jadegoud Yaligar1, Rengaraj Anantharaj1, Le Thi Thu Giang1, Sanjay Kumar Verma1, Venkatesh Gopalan1, Bhanu Prakash K N1, Karthik Mallilankaraman2, and S. Sendhil Velan1

1Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Singapore, Singapore, 2Department of Physiology, National University of Singapore, Singapore, Singapore

High-GI diet has been linked with insulin resistance, type 2 diabetes and cardiovascular risk factors. Brown fat activity positively correlates with increased energy expenditure during β3-agonist/cold induced BAT activation, suggesting regulatory link between BAT and energy metabolism. In this study we evaluated long term metabolic effects of high and low-GI diets on brown adipose tissue metabolism and ectopic fat accumulation in liver and abdomen by MRI and MRS. Low-GI diet fed animals were responsive to prolonged BAT activation for metabolizing the fat. Weight and volumes of iBAT increased with β3-agonist treatment, implying potential remodeling of WAT into Beige.

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