Abstract #2502

Metabolic Imaging of Brown Adipose Tissue in Response to High Glycaemic Diet and Systemic Metabolic Effects on Whole Body Fat Metabolism

Jadegoud Yaligar¹, Rengaraj Anantharaj¹, Le Thi Thu Giang¹, Sanjay Kumar Verma¹, Venkatesh Gopalan¹, Bhanu Prakash K N¹, Karthik Mallilankaraman², and S. Sendhil Velan¹

¹Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Singapore, Singapore, ²Department of Physiology, National University of Singapore, Singapore, Singapore

High-GI diet has been linked with insulin resistance, type 2 diabetes and cardiovascular risk factors. Brown fat activity positively correlates with increased energy expenditure during β3-agonist/cold induced BAT activation, suggesting regulatory link between BAT and energy metabolism. In this study we evaluated long term metabolic effects of high and low-GI diets on brown adipose tissue metabolism and ectopic fat accumulation in liver and abdomen by MRI and MRS. Low-GI diet fed animals were responsive to prolonged BAT activation for metabolizing the fat. Weight and volumes of iBAT increased with β3-agonist treatment, implying potential remodeling of WAT into Beige.

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