Abstract #2501

Metabolic Imaging and Characterization of Browning Adipose Tissue by DCE-MRI and Dixon Imaging

Jadegoud Yaligar¹, Sanjay Kumar Verma¹, Venkatesh Gopalan¹, Rengaraj Anantharaj¹, Giang Le Thi Thu¹, and S. Sendhil Velan¹

¹Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Singapore, Singapore

Browning of white adipose tissues is emerging as a promising strategy to increase whole body energy expenditure and to reduce obesity. At a whole body level, increasing the beige or BAT volume and enhancing its functional activity is a promising strategy for management of obesity. There is a lack of non-invasive methods for imaging the browning process. For the first time we demonstrated the feasibility of non-invasive imaging of browning adipose tissue by fat fraction imaging and DCE-MRI. The browning adipose tissues show significant reduction in fat fraction and increase in tissue perfusion parameters including K^trans and v_e

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