Abstract #2505

Evaluation of Simultaneous MRI/PET of Supraclavicular BAT for Detecting Adaptive Thermogenesis after Sympathetic Nervous System Activation

Sanjay K Verma¹, Lijuan Sun², Suresh Anand Sadananthan³, Navin Michael³, Hui Jen Goh², Priya Govindharajulu², John Totman⁴, David Townsend⁴, Houchun H Hu⁵, Melvin Khee-Shing Leow^2,6, and S Sendhil Velan^1,3

¹Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Agency for Science Technology and Research (A*STAR), Singapore, Singapore, ²Clinical Nutrition Research Centre, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore, ³Singapore Institute of Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore, ⁴Clinical Imaging Research Centre, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore, ⁵Department of Radiology, Nationwide Children's Hospital Columbus, Columbus, OH, United States, ⁶Department of Endocrinology, Tan Tock Seng Hospital, Singapore, Singapore

There is a large interest in detecting and quantifying brown adipose tissue (BAT) in humans for evaluating its potential to design therapeutic strategies to combat obesity-related metabolic dysfunction. In the current study, we evaluated the use of simultaneous PET/MRI of supraclavicular BAT (sBAT) for distinguishing subjects with high or low adaptive thermogenesis after sympathetic nervous system activation by cold exposure and capsinoids ingestion. As a sub-study, We also evaluated the duration of cold-exposure for changes in 18F-FDG uptake and Dixon-based fat-fraction. We found that adaptive thermogenesis after capsinoids ingestion was too low to be detected by either modality, while PET was successful in identifying high responders to cold stimulation.

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