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Abstract #2506

In Vivo Diffusion Magnetic Resonance Spectroscopy of Brown and White Adipose tissues

Sanjay K Verma1, Kavita Kaur1, Jadegoud Yaligar1, Navin Michael2, Anantharaj Rengaraj1, Le Thi Thu Giang1, Venkatesh Gopalan1, Suresh Anand Sadananthan2, Melvin Khee-Shing Leow3,4, and S Sendhil Velan1,2

1Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Agency for Science Technology and Research (A*STAR), Singapore, Singapore, 2Singapore Institute of Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore, 3Clinical Nutrition Research Centre, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore, 4Department of Endocrinology, Tan Tock Seng Hospital, Singapore, Singapore

There is a large interest in understanding the biophysical properties of BAT, WAT, and beige adipose tissues for evaluating its potential to improve whole body metabolism. Diffusion properties of tissues provide information on microstructure, anisotropy, and pathology. In the presence of cellular and sub-cellular barriers, and heterogeneity the lipid diffusion is restricted. Water diffusion has been well characterized in several organs. Fat diffusion has not been studied due to the hardware limitations. In this study, we have implemented diffusion-weighted spectroscopy for investigating in-vivo diffusion properties of BAT and WAT.

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