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Abstract #2507

The Associations between Water-Fat MRI Measurements of Brown Adipose Tissue and Abdominal Adiposity and Glucose Metabolism in Children and Adolescents

Elin Lundström1, Joy Ljungberg1, Jonathan Andersson1, Robin Strand1,2, Anders Forslund3,4, Peter Bergsten5, Daniel Weghuber6,7, Katharina Paulmichl6,7, Kurt Widhalm6,7, Matthias Meissnitzer8, Håkan Ahlström1,9, and Joel Kullberg1,9

1Department of Radiology, Uppsala University, Uppsala, Sweden, 2Department of Information Technology, Uppsala University, Uppsala, Sweden, 3Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden, 4Children Obesity Clinic, Uppsala University Hospital, Uppsala, Sweden, 5Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden, 6Department of Paediatrics, Paracelsus Medical University, Salzburg, Austria, 7Obesity Research Unit, Paracelsus Medical University, Salzburg, Austria, 8Department of Radiology, Paracelsus Medical University, Salzburg, Austria, 9Antaros Medical, BioVenture Hub, Mölndal, Sweden

Investigating the role of brown fat (BAT) in child/adolescent metabolism and obesity is important for elucidating its potential as an antiobesity/antidiabetes therapeutic target. This study presents associations between MRI estimates of BAT (by cervical-supraclavicular adipose tissue fat fraction and T2*) and abdominal adiposity and glucose metabolism parameters in children/adolescents. Associations between the BAT estimates and adiposity were observed, supporting previous indications of decreasing BAT amounts with increasing adiposity. Additional associations between the BAT estimates and important glucose metabolism parameters may reflect a role for BAT in glucose and energy metabolism and potentially a link to development of type 2 diabetes.

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