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Abstract #2509

Using water-fat MRI to detect remodeling of adipose tissue

Amanda DV MacCannell1, Kevin J Sinclair 2, James F Staples1, and Charles A McKenzie2

1Biology, Western University, London, ON, Canada, 2Medical Biophysics, Western University, London, ON, Canada

Hibernating mammals use brown adipose tissue (BAT) as a primary source of heat production for arousal from torpor. In hibernators, both white adipose tissue (WAT) and BAT volumes increase in autumn even when temperatures are warm, unlike non-hibernators which require cold exposure for BAT growth. Differentiation of WAT from BAT between depots in close proximity can be achieved using IDEAL water-fat MRI. Hibernating mammals exposed to constant warm environments showed drastic molecular changes to their BAT depots that could ultimately be detected my MRI, proving IDEAL’s versatility and specificity.

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