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Abstract #2510

Novel model of alcoholic hepatitis and alcoholic steatohepatitis using C57BL/6N mice and magnetic resonance imaging/spectroscopy

Jeeheon Kang1, Su Jung Ham1, Yoonseok Choi2, Seul-I Lee1, Jinil Kim1, Jae Im Kwon1, Ho-jin Kim1, Do-Wan Lee1, YongJun Lee3, Chul-Woong Woo1, Sang Tae Kim1, Kyung Won Kim1, and Dong-Cheol Woo1

1Asan Medical Center, Seoul, Republic of Korea, 2Gangneung Asan Hospital, Gangneung, Republic of Korea, 3Hongcheon Institute of Medical Herb, Hongcheon, Republic of Korea

Alcoholic liver disease is classified into two subgroups: alcoholic hepatitis (AH) and alcoholic steatohepatitis (ASH). These differ in most characteristics, including clinicopathologic features and treatment. However, animal models of AH and ASH are not well established. Noninvasive monitoring is essential for evaluating chronic diseases such as AH and ASH. Magnetic resonance imaging and spectroscopy (MRI/S) have recently gained considerable attention as noninvasive monitoring tools for chronic liver disease. The aim of this study, therefore, was to develop a comprehensive animal model of AH and ASH that can be monitored noninvasively using MRI/S.

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