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Abstract #2511

ADC quantification of lipids with high b-value stimulated echo-prepared diffusion-weighted 2D single shot TSE

Dominik Weidlich1, Stefan Ruschke1, Barbara Cervantes1, Andreas Hock2, and Dimitrios C. Karampinos1

1Department of Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany, 2Philips Healthcare, Hamburg, Germany

The prevalence of the metabolic syndrome is rapidly growing over the past decade. Fat plays a central role in the incidence and the progression of the metabolic syndrome and despite the successful clinical translation of quantitative fat MRI biomarkers into applications, current MRI biomarkers cannot answer questions about fat cell microstructure in different fat depots. This work proposes an acquisition imaging method that probes the diffusion properties of lipids, compares the proposed method to single-voxel diffusion-weighted MRS in vivo in the tibia bone marrow and investigates in vivo the dependency of ADC quantification on voxel size in gluteal fat.

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