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Abstract #2526

Development of a fast 4D-MRI with sub-second volumetric frame rate for respiratory motion tracking in abdominal radiotherapy

Jing Yuan1, Yihang Zhou1, Oilei Wong1, KinYin Cheung1, and Siu Ki Yu1

1Medical physics and research department, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong

Time-resolved volumetric MRI (4D-MRI) is gaining more interests for better tumor motion characterization than 4D-CT in abdominal radiotherapy, while 3D sequence has limited use for 4D-MRI acquisition due to its slow volume-frame-rate (VFR) and various motion artifacts. We developed a fast 4D-MRI technique based on CAIPIRINHA accelerated 3D spoiled gradient echo sequence and a 1.63 frames-per-second (615ms/frame, ~1/7 of normal respiratory cycle of 4-5s) VFR was achieved. This 4D-MRI was demonstrated for whole abdomen respiratory motion tracking in healthy volunteers, indicating its great potentials for internal-target-volume definition in radiotherapy treatment planning and image guidance of MR-guided-radiotherapy.

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