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Abstract #2527

A study of correlation of the SUVmax and ADC in malignant breast tumors using simultaneous PET-MRI

Jing Yuan1, Gladys Goh Lo2, Garrett CL Ho3, Sirong Chen1, Helen HL Chan2, Victor HG Ai2, William SK Cheung3, Catherine YH Wong3, Suk Yee Polly Cheung4, and Ting Ting Wong4

1Medical physics and research department, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong, 2Department of diagnostic & interventional radiology, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong, 3Department of nuclear medicine &positron emission tomography, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong, 4Breast Care Center, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong

We studied the correlation of simultaneous DWI-ADC and 18F-FDG SUVmax in invasive ductal carcinoma (IDC) tumors (n=41), and their association with different diagnostic factors using integrated PET-MRI. An insignificant inverse correlation was found (r=-0.214, p=0.179) between SUVmax and ADCmean. SUVmax was significantly associated with tumor T-stage (p=0.024). ADCmean of the index IDC was significantly smaller in the patients with pathologically confirmed regional lymph node metastasis (p=0.0488) and estrogen receptor status (p=0.0254). An insignificantly larger SUVmax (p=0.1352) was found in triple negative IDCs. Our results showed that SUVmax and ADCmean might potentially have complementary roles in breast cancer characterization.

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