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Abstract #2531

MR Imaging Perfusion and Diffusion analysis to assess preoperative Short Course Radiotherapy response in locally advanced rectal cancer: Standardized Index of Shape by DCE-MRI and Intravoxel Incoherent Motion derived parameters by DW-MRI

Roberta Fusco1 and Antonella Petrillo1

1National Cancer Institute of Naples Pascale Foundation, Naples, Italy

Aim of this study is to determine the diagnostic performance of MR imaging for the assessment of tumor response after Short Course Radiotherapy (SCR) in patients with LARC using Standardized Index of Shape (SIS) obtained by DCE-MRI and using ADC, DKI and IVIM derived parameters obtained by DW-MRI.

We demostrated that SIS is a hopeful DCE-MRI angiogenic biomarker to assess preoperative treatment response after SCR with delayed surgery and it permits to discriminate pCR allowing to direct surgery for tailored and conservative treatment.

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