While CAD is already routinely employed in conventional mammography, the data available on CAD cancer detection at MRI so far are limited and mostly include evaluation of lesion size, vascularization kinetics and tumor extent. Our data from two different approaches based on the percentage of voxel volume enhancement of either the ipsilateral breast alone or accounting for background parenchymal enhancement measured in the contralateral breast suggest both to be viable approaches for breast cancer detection with excellent reproducibility, that should be further developed.
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