Abstract #2548

Amide Proton Transfer (APT) MR imaging and Magnetization Transfer (MT) MR imaging of liver cirrhosis: a clinical feasibility study

Xin Chen^1,2, Guangbin Wang¹, Jinyuan Zhou², Yi Zhang^2,3, Weibo Chen⁴, and Huihua Li¹

¹Shandong Medical Imaging Research Institute, Jinan, China, ²Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Center for Brain Imaging Science and Technology, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China, ⁴Philips Healthcare, Shanghai, China

This study aimed to demonstrate the feasibility of the APT and MT MR imaging in depicting the liver cirrhosis at 3.0T. We compared MTR and APTw values in 11 healthy livers and 8 liver cirrhosis. The patients with liver cirrhosis showed a lower APTw values than healthy volunteers indicating APT imaging detectable mobile protein levels in the liver tissues. The patients with liver cirrhosis exhibited a higher MTR values than the healthy volunteers. Liver cirrhosis exhibited a significantly higher MTR, indicating indicating a higher concentration of biochemistry components in liver cirrhosis. We have shown that it is clinically feasible to perform APT and MT MR imaging of liver cirrhosis.

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