Abstract #2549

Vessel Size Imaging for Liver Fibrosis Staging Based on Dynamic Susceptibility Contrast Using SE/GRE-EPI Sequence：Comparison with US Elastography and Histopathological Correlation

Ruo-kun Li¹, Fu-hua Yan¹, Wei-bo Chen², and He Wang³

¹Radiology, Ruijin Hospital, Shanghai Jiaotong University School of Medcine, Shanghai, China, ²Philips Healthcare, Shanghai, China, ³Institute of Science and Technology for Brain-Inspired Intelligence, Shanghai, China

The study investigated the value of vessel size imaging (VSI) based on dynamic susceptibility contrast using SE/GRE-EPI sequence for liver fibrosis staging, compared with US elastography and correlated with histopathological results. We found that VVF and Nu value based on VSI were independent predicative factors of liver fibrosis (R2=0.566，P=0.002). They had correlation with hepatic sinusoidal structures including parenchymal area (PA), sinusoidal area (SA), hepatocyte area (HA), sinusoidal perimeter (SP), SA/SP ratio, SA/SP index, and HA/SP index. Microvessel density (MVDdensity) and area (MVDarea). VSI has potential for liver fibrosis staging with good diagnostic capability similar to US elastography.

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